Lin Lab

Overview

Electrochemistry Tutorials

High-Throughput Electrochemistry

Wireless Electrochemistry

High-Throughput Electrochemistry

Accelerating Electrosynthesis

HTe^–Chem offers a standardized platform for high-throughput electrochemical experimentation in a compact 24-well plate microscale reactor compatible with existing HTE infrastructure such as multichannel pipettors and reagent handling robotics.

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HTe^–Chem is designed to enable the rapid evaluation of a broad array of electrochemical reaction parameters to accelerate reaction discovery, optimization, and chemical library synthesis.

Features

Standardized 3x2” reactor compatible with existing HTE technology
4x6 well array for screening 4 currents/voltages simultaneously
Reactor block can be heated or cooled and has a temperature probe
Compatible with electrophotochemistry via illumination from the base

Reaction Optimization Using HTe^–Chem

In addition to standard reaction parameters, the HTe^–Chem platform offers the ability to screen electrochemical parameters such as electrode material, current, potential, and reaction time. The following two examples demonstrate how HTe^–Chem accelerated the optimization of electrochemical and electrophotochemical reactions.

Reduction allylic silylation (Original work: JACS 2020, 142, 21272)

Electrophotocatalytic C—H amination (Original work: ACIE 2019, 58, 13318)

Reaction Optimization Using HTe^–Chem

Reduction allylic silylation (Original work: JACS 2020, 142, 21272)

Electrophotocatalytic C—H amination (Original work: ACIE 2019, 58, 13318)

Accelerate Your Electrosynthesis

Our partnership with Merck and Analytical Sales makes HTe^–Chem available to the broader synthetic community.

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Showcasing Publications

1.
Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis
Cecilia Bottecchia, Dan Lehnherr, François Lévesque, Mikhail Reibarkh, Yining Ji, Vailankanni L. Rodrigues, Heather Wang, et al.

Org. Process Res. Dev. 2022, 26, 2423–2437
2.
Persistent Organonickel Complexes as General Platforms for Csp2-Csp3 Coupling Reactions
Long P. Dinh, Hunter F. Starbuck, Taylor B. Hamby, Matt J. LaLama, Cyndi Q. He, Dipannita Kalyani, and Christo S. Sevov

Nat. Chem. 2024, 16, 1515–1522.
3.
Nickel-Catalyzed Electroreductive Coupling of Alkylpyridinium Salts and Aryl Halide
Jiantao Fu, Windsor Lundy, Rajdip Chowdhury, J. Cameron Twitty, Long P. Dinh, Jessica Sampson, Yu-hong Lam, Christo S. Sevov, Mary P. Watson, and Dipannita Kalyani

ACS Catal. 2023, 13, 9336–9345
4.
Diastereoselective Reductive Etherification Via High-Throughput Experimentation: Access to Pharmaceutically Relevant Alkyl  Ethers
Jiantao Fu, Zoe Vaughn, Andrew F. Nolting, Qi Gao, Dexi Yang, Christopher H. Schuster, and Dipannita Kalyani

J. Org. Chem. 2023, 88, 13454–13465
5.
Primary vs. Secondary Alkylpyridinium Salts: A Comparison under Electrochemical and Chemical Reduction Conditions
Bria Garcia, Jessica Sampson, Mary P. Watson, and Dipannita Kalyani

Faraday Discussions. 2023, 247, 324–332
6.
Accelerated Analysis of the Electrochemical Production Route for Biomass-Derived Adiponitrile
Ricardo Mathison, Elina Rani, Meera K. Patel, Casey K. Bloomquist, Antonio Lopez Cerrato, and Miguel A. Modestino
ChemRxiv. 2024
7.
Electrosynthesis of Iminophosphoranes and Applications in Nickel Catalysis
Velabo Mdluli, Dan Lehnherr, Yu-hong Lam, Mohammad T. Chaudhry, Justin A. Newman, Jimmy O. DaSilva, and Erik L. Regalado

Chem. Sci. 2024, Advance Article
8.
High-Throughput Photo- and Electrochemical Sp2–Sp3 Cross-Electrophile Coupling to Access Novel Tedizolid Analogs
Montero Bastidas, Jose Raul, Scott L’Heureux, Wenbin Liu, Ken Lee, and Abdellatif El Marrouni

ACS Med. Chem. Lett. 2023, 14, 666–671
9.
Exploring Electrochemical C(Sp3)–H Oxidation for the Late-Stage Methylation of Complex Molecules
Luiz F. T. Novaes, Justin S. K. Ho, Kaining Mao, Kaida Liu, Mayank Tanwar, Matthew Neurock, Elisia Villemure, Jack A. Terrett, and Song Lin

J. Am. Chem. Soc. 2022, 144, 1187–1197
10.
Generality-Oriented Optimization of Enantioselective Aminoxyl Radical Catalysis
Jonas Rein, Soren D. Rozema, Olivia C. Langner, Samson B. Zacate, Melissa A. Hardy, Juno C. Siu, Brandon Q. Mercado, Matthew S. Sigman, Scott J. Miller, and Song Lin

Science. 2023, 380, 706–712
11.
Electrochemical Recycling of Adenosine Triphosphate in Biocatalytic Reaction Cascades
Serge Ruccolo, Gilmar Brito, Melodie Christensen, Tetsuji Itoh, Keith Mattern, Kevin Stone, Neil A. Strotman, and Alexandra C. Sun

J. Am. Chem. Soc. 2022, 144, 22582–22588
12.
Intercepting Hydrogen Evolution with Hydrogen-Atom Transfer: Electron-Initiated Hydrofunctionalization of Alkenes
Xiangyu Wu, Cara N. Gannett, Jinjian Liu, Rui Zeng, Luiz F. T. Novaes, Hongsen Wang, Héctor D. Abruña, and Song Lin

J. Am. Chem. Soc. 2022, 144, 1187–1197
13.
Enabling Electrochemical, Decarboxylative C(sp2)–C(sp3) Cross-Coupling for Parallel Medicinal Chemistry
Jennifer Morvan, Bingqing Tang, Pavel Ryabchuk, Evelien Renders, Stefaan Last, Lars Van Eynde, Karolina Bartkowiak, Peter J. J. A. Buijnsters, Alexander X. Jones, Mary-Ambre Carvalho, and Justin B. Diccianni
Eur. J. Med. Chem. 2025, 291, 117583.

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